The spindle checkpoint ensures the fidelity of chromosome segregation by preventing cell-cycle progression until all the chromosomes make proper bipolar attachments to the mitotic spindle and come under tension. Despite significant advances in our understanding of spindle checkpoint function, the primary signal that activates the spindle checkpoint remains unclear. Whereas some experiments indicate that the checkpoint recognizes the lack of microtubule attachment to the kinetochore, others indicate that the checkpoint senses the absence of tension generated on the kinetochore by microtubules. The interdependence between tension and microtubule attachment make it difficult to determine whether these signals are separable. In this article (which is part of the Chromosome Segregation and Aneuploidy series), we consider recent evidence that supports and opposes the hypothesis that defects in tension act as the primary checkpoint signal.

中文翻译：

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主轴检查点：张力与附件。

纺锤体检查点通过防止细胞周期进程，直到所有染色体与有丝分裂纺锤体形成适当的双极附着并受到张力，来确保染色体分离的保真度。尽管在了解主轴检查点功能方面取得了重大进展，但激活主轴检查点的主要信号仍不清楚。尽管一些实验表明检查点认识到微管没有附着在动粒上，但其他实验表明检查点感觉到没有微管在动粒上产生张力。张力和微管附着之间的相互依赖性使得很难确定这些信号是否可分离。在本文中（这是染色体分离和非整倍性系列的一部分），