We investigated the potential hepatoprotective effects of misoprostol (MP) on doxorubicin (DOX) induced liver injury in rats using histology and biochemistry. We used 21 male Sprague-Dawley rats divided randomly into three groups: group 1, control; group 2, DOX; group 3, DOX + MP. The control group was injected intraperitoneally (i.p.) with 0.5 ml 0.9% w/v NaCl and given 1 ml 0.9% NaCl orally for 6 days. DOX was administered i.p. as a single dose of 20 mg/kg. MP, 0.2 mg/kg, was given orally for 6 days. Treatment with MP increased high density lipoprotein cholesterol levels and decreased serum alanine aminotransferase, aspartate aminotransferase, low density lipoprotein cholesterol, triglycerides and total cholesterol levels significantly in serum. Increased malondialdehyde level and decreased catalase, glutathione and superoxide dismutase levels caused by DOX were suppressed significantly in liver tissue by MP. DOX + MP reduced loss of body weight. Oxidative stress was decreased, antioxidant activity was increased and histopathological changes were reduced in the DOX + MP group compared to the DOX group. Liver injury caused by DOX was attenuated by MP treatment owing to the antioxidative and anti-apoptotic effects of MP, which might be useful for reducing the severity of DOX induced liver injury.

中文翻译：

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米索前列醇对阿霉素引起的肝损伤的保护作用。

我们使用组织学和生物化学方法研究了米索前列醇（MP）对阿霉素（DOX）诱导的大鼠肝损伤的潜在肝保护作用。我们使用21只雄性Sprague-Dawley大鼠随机分为三组：第1组，对照组；第2组，第2组。第2组，DOX；第3组，DOX + MP。对照组腹膜内（ip）注射0.5 ml 0.9％w / v NaCl，口服1 ml 0.9％NaCl，持续6天。腹腔注射DOX剂量为20 mg / kg。口服MP，0.2 mg / kg，持续6天。MP治疗可显着提高血清中高密度脂蛋白胆固醇水平，并降低血清丙氨酸氨基转移酶，天冬氨酸转氨酶，低密度脂蛋白胆固醇，甘油三酸酯和总胆固醇水平。丙二醛水平升高而过氧化氢酶降低，MP显着抑制DOX引起的谷胱甘肽和超氧化物歧化酶水平。DOX + MP减少了体重减轻。与DOX组相比，DOX + MP组的氧化应激降低，抗氧化活性增强，组织病理学变化降低。由于MP的抗氧化和抗凋亡作用，MP处理可减轻DOX引起的肝损伤，这可能有助于减轻DOX引起的肝损伤的严重性。