Over the past four decades, Drosophila melanogaster has become an increasingly important model system for studying the modulation of chemical synapses and muscle contraction by cotransmitters and neurohormones. This review describes how advantages provided by Drosophila have been utilized to investigate synaptic modulation, and it discusses key findings from investigations of cotransmitters and neurohormones that act on body wall muscles of 3rd instar Drosophila larvae. These studies have contributed much to our understanding of how neuromuscular systems are modulated by neuropeptides and biogenic amines, but there are still gaps in relating these peripheral modulatory effects to behavior.

在过去的四十年中，果蝇已经成为一个越来越重要的模型系统，用于研究辅助递质和神经激素对化学突触的调节和肌肉收缩。这篇综述描述了果蝇所提供的优势如何被用于研究突触调节，并讨论了对作用于三龄果蝇幼虫体壁肌肉的共递质和神经激素的研究中的关键发现。这些研究为我们对神经肽和生物胺如何调节神经肌肉系统的理解做出了很大贡献，但是在将这些外周调节作用与行为联系起来方面仍然存在空白。