The oxidation of a vast range of phenolic and non-phenolic substrates has been catalyzed by laccases. Given a wide range of substrates, laccases can be applied in different biotechnological applications. The present review was conducted to provide a broad context in pharmaceutical- and biomedical- related applications of laccases for academic and industrial researchers. First, an overview of biological roles of laccases was presented. Furthermore, laccase-mediated strategies for imparting antimicrobial and antioxidant properties to different surfaces were discussed. In this review, laccase-mediated mechanisms for endowing antimicrobial properties were divided into laccase-mediated bio-grafting of phenolic compounds on lignocellulosic fiber, chitosan and catheters, and laccase-catalyzed iodination. Accordingly, a special emphasis was placed on laccase-mediated functionalization for creating antimicrobials, particularly chitosan-based wound dressings. Additionally, oxidative bio-grafting and oxidative polymerization were described as the two main laccase-catalyzed reactions for imparting antioxidant properties. Recent laccase-related studies were also summarized regarding the synthesis of antibacterial and antiproliferative agents and the degradation of pharmaceuticals and personal care products.

中文翻译：

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漆酶的生物医学和制药相关应用。

漆酶催化了多种酚和非酚底物的氧化。给定各种各样的底物，漆酶可以应用于不同的生物技术应用中。进行本综述旨在为学术和工业研究人员提供漆酶在药物和生物医学相关应用方面的广泛背景。首先，介绍了漆酶的生物学作用。此外，讨论了将漆酶介导的策略赋予不同表面抗微生物和抗氧化性能。在这篇综述中，漆酶介导的赋予抗菌性能的机制被分为漆酶介导的酚类化合物在木质纤维素纤维，壳聚糖和导管上的生物接枝以及漆酶催化的碘化。因此，特别强调了漆酶介导的功能化以产生抗微生物剂，特别是基于壳聚糖的伤口敷料。另外，氧化生物接枝和氧化聚合被描述为赋予抗氧化剂性能的两个主要的漆酶催化反应。还总结了有关漆酶的最新研究，涉及抗菌和抗增殖剂的合成以及药物和个人护理产品的降解。