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Phytochemicals and Potential Therapeutic Targets on Toxoplasma gondii Parasite.
Mini-Reviews in Medicinal Chemistry ( IF 3.3 ) Pub Date : 2020-01-01 , DOI: 10.2174/1389557519666191029105736
Sharif Alhassan Abdullahi 1, 2 , Ngah Zasmy Unyah 1 , Noshariza Nordin 3 , Rusliza Basir 4 , Wana Mohammed Nasir 1, 5 , Ashraf Ahmad Alapid 1, 6 , Yahaya Hassan 1, 7 , Tijjani Mustapha 1, 8 , Roslaini Abd Majid 1
Affiliation  

Identification of drug target in protozoan T. gondii is an important step in the development of chemotherapeutic agents. Likewise, exploring phytochemical compounds effective against the parasite can lead to the development of new drug agent that can be useful for prophylaxis and treatment of toxoplasmosis. In this review, we searched for the relevant literature on the herbs that were tested against T. gondii either in vitro or in vivo, as well as different phytochemicals and their potential activities on T. gondii. Potential activities of major phytochemicals, such as alkaloid, flavonoid, terpenoids and tannins on various target sites on T. gondii as well as other related parasites was discussed. It is believed that the phytochemicals from natural sources are potential drug candidates for the treatment of toxoplasmosis with little or no toxicity to humans.

中文翻译:

弓形虫寄生虫的植物化学物质和潜在治疗目标。

在刚体弓形虫中鉴定药物靶标是开发化学治疗剂的重要步骤。同样,探索对寄生虫有效的植物化学化合物可导致开发新药,可用于预防和治疗弓形虫病。在这篇综述中,我们搜索了有关在体外或体内针对弓形虫进行测试的草药的相关文献,以及不同的植物化学物质及其对弓形虫的潜在活性。讨论了主要植物化学物质(如生物碱,类黄酮,萜类化合物和丹宁酸)在弓形虫以及其他相关寄生虫上不同靶位上的潜在活性。
更新日期:2019-11-01
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