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An Introduction to Pathology in Biomedical Research: A Mission-Critical Specialty for Reproducibility and Rigor in Translational Research.
ILAR Journal ( IF 2.5 ) Pub Date : 2019-07-23 , DOI: 10.1093/ilar/ilz008
Cory F Brayton 1 , Kelli L Boyd 2 , Jeffrey L Everitt 3 , David K Meyerholz 4 , Piper M Treuting 5 , Brad Bolon 6
Affiliation  

This issue of ILAR Journal focusses on pathology and pathologists in biomedical research, more specifically in preclinical translational research involving (nonhuman) animals, emphasizing academic settings. Considerations in study design and planning to maximize benefit from pathologists and pathology resources are reviewed. Adjunctive technologies including molecular techniques, digital pathology, and imaging are highlighted. Additional considerations regarding safety and regulatory concerns, and veterinary clinical trials are reviewed as well. Pathology has been fundamental to understanding clinical disease, remains fundamental to diagnosing disease, and is required in drug and device development. Broader integration of pathology expertise and well-designed pathology investigations have much to offer research rigor and reproducibility, and successful translation from biomedical research.

中文翻译:

生物医学研究中的病理学简介:转化研究的可重复性和严格性的任务关键型专业。

本期《 ILAR杂志》侧重于生物医学研究中的病理学和病理学家,尤其是涉及(非人类)动物的临床前转化研究,强调学术背景。回顾了研究设计和规划中要从病理学家和病理资源中获得最大收益的考虑因素。重点介绍了辅助技术,包括分子技术,数字病理学和成像技术。还审查了有关安全性和监管问题以及兽医临床试验的其他注意事项。病理学一直是了解临床疾病的基础,仍然是诊断疾病的基础,并且是药物和设备开发所必需的。病理学专业知识和精心设计的病理学研究之间的广泛整合为我们提供了严谨的研究和可重复性,
更新日期:2019-11-01
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