Intermediate phenotypes of microcirculation (retinal microvascular caliber) are associated with cardiovascular (CV) risk factors and independently predict CV events. However, the effect of microcirculation variation on the vascular system is unclear. We conducted a systematic review and meta‐analysis of observational studies to quantify associations of retinal microvascular caliber (arteriolar, venular caliber, arteriole‐to‐venule ratio) and preclinical CV measures (large arterial function and structure).

中文翻译：

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视网膜微血管口径与大动脉功能和结构的中间表型的关联：系统评价和荟萃分析。

微循环的中间表型（视网膜微血管口径）与心血管（CV）危险因素有关，并独立预测CV事件。但是，微循环变化对血管系统的影响尚不清楚。我们对观察性研究进行了系统的回顾和荟萃分析，以量化视网膜微血管口径（小动脉，小静脉口径，小动脉与小静脉比率）和临床前CV量度（大动脉功能和结构）的关联。