A novel pulsatile assist device, intra-ventricular assist device, was proposed to address various disadvantages existing in conventional pulsatile assist device, such as the large size, accessories and reduced pulsatility. The assist device was designed, fabricated and implanted into the sac from left ventricular apex in a home-designed mock circulatory system. In vitro test was carried out and results demonstrated that the response time did not vary with the heart rate, and co-pulsatiled synchronously with native heart by electrocardiograph. The key parameter, stroke volume of proposed device was precisely measured under different afterloads (60, 80, 100, and 120 mmHg), drive pressure (from 90 to 300 mmHg at 30 mmHg intervals), and heart rate (45–150 beats per minute). The measurement results revealed that the output characteristics of device, stroke volume increased with increasing drive pressure but decreased with increasing peripheral resistance, were consistent with the native heart. The proposed pump was then coupled with mock system that was set to a heart failure mode and the circulatory responses were tested. Results showed that the device improved left ventricular pressure from 106 to 158 mmHg, and stroke volume from 25.5 to 44 ml at 90 bpm.

提出了一种新颖的脉动辅助装置，即心室内辅助装置，以解决常规脉动辅助装置中存在的各种缺点，例如尺寸大，附件少和脉动性降低。在家庭设计的模拟循环系统中，将辅助装置设计，制造并从左心尖植入囊中。进行了体外测试，结果表明响应时间不随心率而变化，并且通过心电图仪与自然心脏同步脉动。关键参数，拟议设备的搏动量是在不同的后负荷（60、80、100和120 mmHg），驱动压力（每30 mmHg间隔从90到300 mmHg）和心律（每45-150次心跳）下精确测量的分钟）。测量结果表明，设备的输出特性，每搏输出量随驱动压力的增加而增加，但随周围阻力的增加而降低，与原发心脏一致。然后，将建议的泵与设置为心力衰竭模式的模拟系统耦合，并测试了循环反应。结果表明，该装置在90 bpm时可使左心室压力从106 mmHg改善到158 mmHg，每搏量从25.5 ml改善到44 ml。