Ten years ago we reviewed how the cellular DNA damage response (DDR) is controlled by changes in the functional and structural properties of nuclear proteins, resulting in a timely coordinated control of gene expression that allows DNA repair. Expression of genes that play a role in DDR is regulated not only at transcriptional level during mRNA biosynthesis but also by changing steady-state levels due to turnover of the transcripts. The 3' end processing machinery, which is important in the regulation of mRNA stability, is involved in these gene-specific responses to DNA damage. Here, we review the latest mechanistic connections described between 3' end processing and DDR, with a special emphasis on alternative polyadenylation, microRNA and RNA binding proteins-mediated deadenylation, and discuss the implications of deregulation of these steps in DDR and human disease. This article is categorized under: RNA Processing > 3' End Processing RNA-Based Catalysis > Miscellaneous RNA-Catalyzed Reactions RNA in Disease and Development > RNA in Disease.

中文翻译：

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3' 末端加工和 DNA 损伤反应之间的联系：十年后。


十年前，我们回顾了如何通过核蛋白功能和结构特性的变化来控制细胞 DNA 损伤反应 (DDR)，从而及时协调控制基因表达，从而实现 DNA 修复。在 DDR 中发挥作用的基因的表达不仅在 mRNA 生物合成过程中的转录水平上受到调节，而且还通过转录本的更新而改变稳态水平来调节。 3' 末端加工机制对于 mRNA 稳定性的调节非常重要，它参与了这些针对 DNA 损伤的基因特异性反应。在这里，我们回顾了 3' 末端加工和 DDR 之间描述的最新机制联系，特别强调替代性多腺苷酸化、microRNA 和 RNA 结合蛋白介导的去腺苷酸化，并讨论了这些步骤放松管制对 DDR 和人类疾病的影响。本文分类如下： RNA 处理 > 3' 末端处理 基于 RNA 的催化 > 其他 RNA 催化反应 RNA 在疾病和发育中的作用 > RNA 在疾病中的作用。