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Inhibitors of Cholinesterases in the Pharmacology, the Current Trends.
Mini-Reviews in Medicinal Chemistry ( IF 3.3 ) Pub Date : 2020-08-31 , DOI: 10.2174/1389557519666191018170908
Miroslav Pohanka 1
Affiliation  

Inhibitors of cholinesterases are a wide group of low molecular weight compounds with a significant role in the current pharmacology. Besides the pharmacological importance, they are also known as toxic compounds like military nerve agents. In the pharmacology, drugs for Alzheimer disease, myasthenia gravis and prophylaxis of poisoning by nerve agents can be mentioned as the relevant applications. Besides this, anti-inflammation and antiphrastic drugs are other pharmacological applications of these inhibitors. This review is focused on a survey of cholinesterase inhibitors with known or expected pharmacological impact and indications of their use. Recent literature with comments is provided here as well.



中文翻译:

胆碱酯酶抑制剂在药理学中的最新趋势。

胆碱酯酶的抑制剂是广泛的低分子量化合物,在目前的药理学中具有重要作用。除了药理学重要性外,它们还被称为有毒化合物,如军用神经毒剂。在药理学中,可以提及用于治疗阿尔茨海默氏病,重症肌无力和预防神经毒剂中毒的药物。除此之外,抗炎和抗痛药是这些抑制剂的其他药理应用。这篇综述的重点是对具有已知或预期药理作用的胆碱酯酶抑制剂及其使用适应症的调查。这里也提供带有评论的最新文献。

更新日期:2020-10-19
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