Genome editing has opened up the possibility of heritable alteration of the human germline. The potential of this powerful tool has spurred a call for establishing robust regulatory frameworks to outline permissible uses of genome editing and to map a rational and ethical course. In response, major national scientific bodies and international organizations have convened and released comprehensive reports outlining recommendations for ethical regulatory frameworks. Significantly, these include an emphasis on public participation and the development of principles to guide future applications of genome editing. While essential, public input and principles are not sufficient to ensure ethical uses of this technology. We propose an approach that relies not only on agreed-upon principles and a democratic process but requires a Human Rights Impact Assessment to evaluate the potential burdens that such biomedical interventions may place on human rights.

中文翻译：

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生殖系基因组编辑的社会和伦理影响：我们如何确保人权？

基因组编辑开辟了人类种系遗传变异的可能性。这种强大工具的潜力促使人们呼吁建立健全的监管框架，以概述基因组编辑的允许用途并绘制合理和道德的路线图。作为回应，主要的国家科学机构和国际组织召集并发布了综合报告，概述了有关道德监管框架的建议。重要的是，这些措施包括强调公众参与以及制定指导基因组编辑未来应用的原则。尽管必不可少，但公众的投入和原则不足以确保该技术的道德使用。