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Motor Impairment and Developmental Psychotic Risk: Connecting the Dots and Narrowing the Pathophysiological Gap.
Schizophrenia Bulletin ( IF 5.3 ) Pub Date : 2019-04-25 , DOI: 10.1093/schbul/sby100
Michele Poletti 1 , Eva Gebhardt 2 , Marianne N Kvande 3 , Judith Ford 4, 5 , Andrea Raballo 3, 6
Affiliation  

The motor system in its manifold articulations is receiving increasing clinical and research attention. This is because motor impairments constitute a central, expressive component of the mental state examination and a key transdiagnostic feature indexing disease severity. Furthermore, within the schizophrenia spectrum, the integration of neurophysiological, developmental, and phenomenological perspectives suggests that motor impairment is not simply a generic, extrinsic proxy of an altered neurodevelopment, but might be more intimately related to psychotic risk. Therefore, an increased understanding, conceptualization, and knowledge of such motor system and its anomalies could empower contemporary risk prediction and diagnostic procedures.

中文翻译:

运动障碍和发展性精神病风险:连接点并缩小病理生理学差距。

歧管运动系统越来越受到临床和研究的关注。这是因为运动障碍构成了精神状态检查的中心表达要素,也是索引疾病严重程度的关键转诊特征。此外,在精神分裂症谱系中,神经生理学,发育和现象学观点的整合表明,运动障碍不仅是神经发育改变的简单,外在替代,而且可能与精神病风险密切相关。因此,对这样的运动系统及其异常的了解,概念化和知识的增强可以增强当代的风险预测和诊断程序。
更新日期:2019-11-01
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