The diastereoselective synthesis of trans-2,6-disubstituted piperidines has been rendered enantioselective by incorporating a catalytic dynamic resolution into the first alkylation step. The method has been applied to the synthesis of (-)-epidihydropinidine and (+)-trans-lupetidine.

中文翻译：

---

应用于 2,6-二取代哌啶的合成的催化动态分辨率：(+)-羽扇豆定和 (-)-表二氢吡啶的制备。

通过将催化动态拆分纳入第一个烷基化步骤，使反式 2,6-二取代哌啶的非对映选择性合成具有对映选择性。该方法已应用于(-)-表二氢吡啶和(+)-反式-卢哌啶的合成。