Lineage-committed effector CD4(+) T cells are generated at the peak of the primary response and are followed by heterogeneous populations of central and effector memory cells. Here we review the evidence that T helper type 1 (T(H)1) effector cells survive the contraction phase of the primary response and become effector memory cells. We discuss the applicability of this idea to the T(H)2 cell, T(H)17 helper T cell, follicular helper T cell (T(FH) cell) and induced regulatory T cell lineages. We also discuss how central memory cells are formed, with an emphasis on the role of B cells in this process.

中文翻译：

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CD4(+) 效应子和中央记忆 T 细胞的起源。

沿袭定向效应CD4(+) T 细胞在主要反应的高峰期生成，然后是异质的中央和效应记忆细胞群。在这里，我们回顾了 T 辅助类型 1 (T(H)1) 效应细胞在主要反应的收缩阶段存活下来并成为效应记忆细胞的证据。我们讨论了这一想法对 T(H)2 细胞、T(H)17 辅助 T 细胞、滤泡辅助 T 细胞（T(FH) 细胞）和诱导调节性 T 细胞谱系的适用性。我们还讨论了中央记忆细胞是如何形成的，重点是 B 细胞在这个过程中的作用。