In this paper, we describe low-permeability components of a microfluidic drug delivery system fabricated with versatile micromilling and lamination techniques. The fabrication process uses laminate sheets which are machined using XY milling tables commonly used in the printed-circuit industry. This adaptable platform for polymer microfluidics readily accommodates integration with silicon-based sensors, printed-circuit, and surface-mount technologies. We have used these methods to build components used in a wearable liquid-drug delivery system for in vivo studies. The design, fabrication, and performance of membrane-based fluidic capacitors and manual screw valves provide detailed examples of the capability and limitations of the fabrication method. We demonstrate fluidic capacitances ranging from 0.015 to 0.15 muL/kPa, screw valves with on/off flow ratios greater than 38000, and a 45times reduction in the aqueous fluid loss rate to the ambient due to permeation through a silicone diaphragm layer.

中文翻译：

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用于微型可穿戴给药系统的低渗透性微流体组件的制造方法和性能

在本文中，我们描述了使用多功能微铣削和层压技术制造的微流体药物输送系统的低渗透性组件。制造过程使用层压板，这些层压板使用印刷电路行业中常用的 XY 铣床加工而成。这种适用于聚合物微流体的适应性平台很容易与硅基传感器、印刷电路和表面贴装技术集成。我们已经使用这些方法构建了用于体内研究的可穿戴液体药物递送系统中使用的组件。基于膜的流体电容器和手动螺旋阀的设计、制造和性能提供了制造方法的能力和局限性的详细示例。我们展示了范围从 0.015 到 0.15 μL/kPa 的流体电容，