Chromatin is the therapeutic target for DNA-binding medicinal agents, yet we know substantially more about the interaction of drugs with naked DNA. Current research is unraveling a dynamic gene- and transcription state-dependent structure for human chromatin and also unveiling differences in nucleosome positioning between cancer and normal cells. Considering observations on the modulation of DNA drug binding and adduct repair by histone packaging suggests potential for targeting specific sites within nucleosomes that coincide with weak points of cancer cells.

中文翻译：

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染色质-新的，旧的药物靶标？

染色质是结合DNA的药物的治疗靶标，但我们对药物与裸露DNA的相互作用了解更多。当前的研究正在揭示人类染色质的动态基因和转录状态依赖性结构，并且还揭示了癌症与正常细胞之间核小体定位的差异。考虑到通过组蛋白包装对DNA药物结合和加合物修复进行调节的观察结果表明，有可能靶向核小体中与癌细胞弱点相符的特定位点。