We extend our basic discrete-event model of Plasmodium falciparum malaria to encom pass circumstances in which multiple pheno typic variants of the parasite circulate within interacting human and mosquito populations, and we compare a version in which variants behave independently to one in which they in teract through shared host immune responses. Relative to the standard hypothesis of statisti cal independence, frequencies of mixed-pheno type infection in humans were as expected in the independent-immunity version and much less than expected in the cross-immunity ver sion ; in both versions, however, such frequen cies in mosquitoes were much greater than expected.

中文翻译：

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混合表型恶性疟原虫疟疾的离散事件模型

我们扩展了恶性疟原虫疟疾的基本离散事件模型，以涵盖寄生虫的多种表型变异在相互作用的人类和蚊子种群中循环的情况，并且我们将变异表现独立的版本与它们相互作用的版本进行比较通过共享宿主免疫反应。相对于统计独立性的标准假设，人类混合表型感染的频率在独立免疫版本中与预期一致，而在交叉免疫版本中远低于预期；然而，在这两个版本中，蚊子的这种频率远高于预期。