(4-Phenoxyphenylsulfonyl)methylthiirane (compound 1) is a highly selective and potent inhibitor of gelatinases that shows considerable promise in animal models for cancer and stroke. The metabolism of compound 1 was investigated in mice, following intraperitoneal administration at 100 mg/kg. Eight metabolites were identified in plasma and urine. The primary routes of metabolism of 1 were hydroxylation at the para-position of the terminal phenyl ring, hydroxylation at the alpha-methylene to the sulfonyl, which lead to the generation of a sulfinic acid, and cysteine conjugation of the thiirane ring. The cysteine adducts arose through addition of glutathione to the thiirane ring. The molecule is extensively metabolized and

中文翻译：

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选择性明胶酶抑制剂（4-苯氧基苯基磺酰基）甲基硫代噻吩的代谢。

（4-苯氧基苯基磺酰基）甲基噻吩烷（化合物1）是一种高度选择性和有效的明胶酶抑制剂，在癌症和中风的动物模型中显示出可观的前景。以100 mg / kg腹膜内给药后，在小鼠中研究了化合物1的代谢。在血浆和尿液中鉴定出八种代谢物。1的主要代谢途径是末端苯环对位的羟基化，α-亚甲基至磺酰基的羟基化（这导致亚磺酸的生成）和硫杂环戊烷环的半胱氨酸缀合。半胱氨酸加合物通过将谷胱甘肽加到硫杂环丁烷环上而产生。该分子被广泛代谢，