DATA SOURCES Medline and the Cochrane library databases were searched and additional studies located by scrutinising publications obtained. STUDY SELECTION Studies included in analysis were randomised controlled trails (RCT) about prevention of alveolar osteitis (AO) that were written in English, French, German or any of the Nordic languages (Danish, Finnish, Icelandic, Norwegian, Swedish). Duplicate publications, those with flawed data and RCT that generally addressed postoperative complications were excluded. DATA EXTRACTION AND SYNTHESIS The RCT were quality assessed using the Jadad scale and then categorised and tabulated, according to the main test interventions, to the following domains: antibiotics trials; chlorhexidine trials; trials of PEPH (an antifibrinolytic-active propylic ester of p-hydrobenzoic acid); and other trials including factorial trials (combined interventions) and factorial test groups of RCT belonging to any of the aforementioned domains. RESULTS A total of 90 publications were identified, from which 32 RCT were included, from 12 different countries, covering the time period 1971-2005. An adequate method of random allocation was reported in 47% of the RCT. Eight different RCT assessed different antibiotic regimens. Tetracycline trials revealed the greatest preventive effects on AO, with absolute risk reductions (ARR) ranging from 12-31% and numbers needed to treat (NNT) ranging from three to eight treated individuals. The effect of chlorhexidine rinses for prevention of AO was studied in five RCT with ARR ranging from 3-25% (NNT, four to 36 treatments). Overall, evidence about chlorhexidine rinses on the prevention of AO was inconclusive, but the available data indicate that 0.12% chlorhexidine rinsing pre-operatively and 7 days postoperatively reduces the frequency of AO following surgical removal of lower third molars. Similarly, evidence for the effectiveness of the antifibrinolytic agent PEPH (considered in three trials) was inconclusive, as was that for the other 18 trials agents. CONCLUSIONS Local treatment with tetracycline, and also 0.12% chlorhexidine rinsing pre-operatively and 7 days postoperatively, seem to have significant and clinically relevant preventive effect on AO following surgical removal of lower third molars.

中文翻译：

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术前洗必泰漱口水可减少干燥牙套的发生。

数据来源搜索Medline和Cochrane图书馆数据库，并通过仔细检查出版物来查找其他研究。研究选择分析中包括以英语，法语，德语或任何北欧语言（丹麦语，芬兰语，冰岛语，挪威语，瑞典语，瑞典语）编写的关于预防肺泡性骨炎（AO）的随机对照试验（RCT）。重复的出版物，数据有缺陷的和RCT的那些通常解决术后并发症的出版物被排除在外。数据提取与综合使用Jadad量表对RCT进行质量评估，然后根据主要的测试干预措施，将其归类和制表到以下领域：抗生素试验；洗必泰试验；PEPH（对-氢苯甲酸的抗纤溶活性丙酸酯）的试验；以及其他试验，包括属于上述任何领域的RCT的阶乘试验（联合干预）和阶乘测试组。结果总共确定了90种出版物，其中包括来自12个不同国家的32个RCT，涵盖了1971-2005年。据报告，有47％的随机对照试验采用了适当的随机分配方法。八种不同的RCT评估了不同的抗生素治疗方案。四环素试验显示对AO的预防作用最大，绝对风险降低（ARR）为12-31％，治疗所需数量（NNT）为3至8个治疗个体。在5个RCT中研究了洗必泰冲洗液对AO的预防作用，其ARR为3-25％（NNT，4至36种治疗）。总体，关于洗必泰冲洗液对防止AO的证据尚无定论，但现有数据表明，术前和术后7天0.12％洗必泰冲洗液可降低手术切除下第三磨牙后的AO频率。同样，抗纤维蛋白溶解剂PEPH（在三项试验中考虑）有效性的证据也无定论，其他18种试验药物也无定论。结论术前和术后7天用四环素进行局部治疗以及0.12％洗必太漂洗对手术切除下第三磨牙后的AO似乎具有显着的临床意义。术前和术后7天洗净12％洗必泰可降低手术切除下颌第三磨牙后的AO频率。同样，抗纤维蛋白溶解剂PEPH（在三项试验中考虑）有效性的证据也无定论，其他18种试验药物也无定论。结论术前和术后7天用四环素进行局部治疗以及0.12％洗必太漂洗对手术切除下第三磨牙后的AO似乎具有显着的临床意义。术前和术后7天洗净12％洗必泰可降低手术切除下颌第三磨牙后的AO频率。同样，抗纤维蛋白溶解剂PEPH（在三项试验中考虑）有效性的证据也无定论，其他18种试验药物也无定论。结论术前和术后7天用四环素进行局部治疗以及0.12％洗必太漂洗对手术切除下第三磨牙后的AO似乎具有显着的临床意义。