Recent evidence has demonstrated that cell-to-cell signaling is a fundamental activity carried out by numerous microorganisms. A number of specialized processes are reported to be regulated by density-dependent signaling molecules including antibiotic production, bioluminescence, biofilm formation, genetic competence, sporulation, swarming motility and virulence. However, a more centralized role for quorum sensing is emerging where quorum signaling pathways overlap with stress and starvation circuits to regulate cellular adaptation to changing environmental conditions. The interplay of these phenomena is especially critical in the expression of recombinant proteins where elicitation of stress responses can dramatically impact cellular productivity.

中文翻译：

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细菌自动诱导：在细胞外寻找新的代谢工程靶标。

最近的证据表明，细胞间信号传导是许多微生物进行的一项基本活动。据报道，许多专门的过程受到密度依赖性信号分子的调节，包括抗生素的产生，生物发光，生物膜的形成，遗传能力，孢子形成，成群运动和毒力。但是，在群体感应中，群体信号传递途径与压力和饥饿电路交叠，以调节细胞对不断变化的环境条件的适应性，群体感应的作用正在逐渐显现。这些现象的相互作用在重组蛋白的表达中尤其重要，在重组蛋白中引起应激反应会极大地影响细胞的生产力。