The development of a single immuno-metabolic adjuvant capable of modulating, in the appropriate direction and intensity, the complex antagonistic and symbiotic interplays between tumor cells, immune cells, and the gut microbiota may appear pharmacologically implausible. Metformin might help solve this conundrum and beneficially impact the state of cancer-immune system interactions.

中文翻译：

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二甲双胍作为癌症免疫疗法的原型免疫代谢佐剂。

能够在适当的方向和强度上调节肿瘤细胞，免疫细胞和肠道菌群之间复杂的拮抗和共生相互作用的单一免疫代谢佐剂的开发可能在药理上是不可信的。二甲双胍可能有助于解决这一难题，并有利地影响癌症与免疫系统相互作用的状态。