Associations between the promoter polymorphism of the serotonin transporter gene (5-HTTLPR) and anxiety-related personality traits in healthy adult subjects have been inconsistent. We assessed personality in participants of the Estonian Children Personality Behaviour and Health Study, using parental reports and self-reports. In the younger cohort, according to parental assessments at ages 9 and 15, children homozygous for the S allele had significantly higher scores of Neuroticism and lower scores of Openness, Agreeableness and Conscientiousness. Parental assessment of the older cohort at ages 15 and 18 did not yield any genotype effect on personality; however, interaction of cohort and genotype was not significant. According to self-reports, SS homozygotes had higher Neuroticism at age 15 but not at age 18. Thus, homozygocity for the S allele of the 5-HTTLPR is related to anxiety-related personality traits in general population, but this is easier to detect before adolescence.

中文翻译：

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个性和血清素转运蛋白基因：纵向人群研究中的关联

健康成人受试者中血清素转运蛋白基因 (5-HTTLPR) 的启动子多态性与焦虑相关人格特征之间的关联一直不一致。我们使用父母报告和自我报告评估了爱沙尼亚儿童人格行为和健康研究参与者的人格。在较年轻的队列中，根据 9 岁和 15 岁父母的评估，S 等位基因纯合子儿童的神经质得分显着较高，而开放性、宜人性和责任心得分较低。父母对 15 岁和 18 岁年龄较大的队列的评估未对人格产生任何基因型影响；然而，队列和基因型的相互作用并不显着。根据自我报告，SS 纯合子在 15 岁时具有较高的神经质，但在 18 岁时没有。因此，