The development of chronic pain involves increased sensitivity of peripheral nociceptors and elevated neuronal activity in many regions of the central nervous system. Much of these changes are caused by the amplification of nociceptive signals resulting from the modulation and altered expression of specific ion channels and receptors in the central and peripheral nervous system. Understanding the processes by which these ion channels and receptors are regulated and how these mechanisms malfunction may lead to new treatments for chronic pain. Here we review the contribution of the Ca2+-permeable acid-sensing ion channel (ASIC(Ca)) in the development and persistence of chronic pain, and the potential underlying mechanisms. Accumulating evidence suggests that ASIC(Ca) represents an attractive new target for developing effective therapies for chronic pain.

中文翻译：

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具有伤害性可塑性的钙可渗透酸感应离子通道：疼痛控制的新目标。

慢性疼痛的发展牵涉到周围伤害感受器的敏感性增加以及中枢神经系统许多区域神经元活性的升高。这些变化中的大部分是由于伤害性信号的放大引起的，该伤害性信号是中枢和周围神经系统中特定离子通道和受体的调节和表达改变而引起的。了解调节这些离子通道和受体的过程以及这些机制如何失灵可能会导致针对慢性疼痛的新疗法。在这里，我们回顾了Ca2 +渗透性酸敏感离子通道（ASIC（Ca））在慢性疼痛的发展和持续中的贡献以及潜在的潜在机制。