Calcium (Ca²⁺) signaling is an essential process in all cells that is maintained by a plethora of channels, pumps, transporters, receptors, and intracellular Ca²⁺ sequestering stores. Changes in cytosolic Ca²⁺ concentration govern processes as far reaching as fertilization, cell growth, and motility through to cell death. In recent years, lysosomes have emerged as a major intracellular Ca²⁺ storage organelle with an increasing involvement in triggering or regulating cellular functions such as endocytosis, autophagy, and Ca²⁺ release from the endoplasmic reticulum. This review will summarize recent work in the area of lysosomal Ca²⁺ signaling and homeostasis, including newly identified functions, and the involvement of lysosome-derived Ca²⁺ signals in human disease. In addition, we explore recent controversies in the techniques used for measurement of lysosomal Ca²⁺ content.

中文翻译：

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健康和疾病中的溶酶体 Ca2+ 稳态和信号传导。

钙 (Ca ²⁺ ) 信号传导是所有细胞中的一个重要过程，由过多的通道、泵、转运蛋白、受体和细胞内 Ca ²⁺隔离储存维持。细胞溶质 Ca ²⁺浓度的变化控制着从受精、细胞生长和运动到细胞死亡的过程。近年来，溶酶体已成为一种主要的细胞内 Ca ²⁺储存细胞器，越来越多地参与触发或调节细胞功能，例如内吞作用、自噬和从内质网释放Ca ^{2+ 。}这篇综述将总结最近在溶酶体 Ca ^{2+领域的工作}信号传导和体内平衡，包括新发现的功能，以及溶酶体衍生的 Ca ²⁺信号在人类疾病中的作用。此外，我们探讨了用于测量溶酶体 Ca ²⁺含量的技术的最新争议。