Abstract Tuberculosis caused by Mycobacterium tuberculosis remains a serious threat to public health. The M. tuberculosis cell envelope is closely related to its virulence and drug resistance. Mycobacterial membrane large proteins (MmpL) are lipid-transporting proteins of the efflux pump resistance nodulation cell division (RND) superfamily with lipid substrate specificity and non-transport lipid function. Mycobacterial membrane small proteins (MmpS) are small regulatory proteins, and they are also responsible for some virulence-related effects as accessory proteins of MmpL. The MmpL transporters are the candidate targets for the development of anti-tuberculosis drugs. This article summarizes the structure, function, phylogenetics of M. tuberculosis MmpL/S proteins and their roles in host immune response, inhibitors and regulatory system.

中文翻译：

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结核分枝杆菌 MmpL/S 家族蛋白的转运机制及其在药物靶向中的意义

摘要 结核分枝杆菌引起的结核病仍然严重威胁着公众健康。结核分枝杆菌细胞包膜与其毒力和耐药性密切相关。分枝杆菌膜大蛋白 (MmpL) 是外排泵抗结节细胞分裂 (RND) 超家族的脂质转运蛋白，具有脂质底物特异性和非转运脂质功能。分枝杆菌膜小蛋白 (MmpS) 是小的调节蛋白，它们作为 MmpL 的辅助蛋白还负责一些毒力相关作用。MmpL 转运蛋白是开发抗结核药物的候选靶标。本文总结了结核分枝杆菌 MmpL/S 蛋白的结构、功能、系统发育及其在宿主免疫反应、抑制剂和调节系统中的作用。