Asymmetric cell divisions are central to the generation of cell-fate diversity because factors that are present in a mother cell and distributed unequally at cell division can generate distinct daughters. The process o f asymmetric cell division can be described as consisting of three steps: setting up an asymmetric cue in the mother cell, localizing factors with respect to this cue, and positioning the plane o f cell division so that localized factors are partitioned asymmetrically between daughters. This review describes how specialized cortical domains play a key role in each of these steps and discusses our current understanding of the molecular nature o f cortical domains and the mechanisms by which they may orchestrate asymmetric cell divisions.

中文翻译：

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皮质区域和不对称细胞分裂的机制。

不对称细胞分裂对于细胞命运多样性的产生至关重要，因为存在于母细胞中并且在细胞分裂中不均匀分布的因子可以产生不同的子代。不对称细胞分裂的过程可以描述为由三个步骤组成：在母细胞中设置不对称线索，相对于该线索的定位因子以及定位细胞分裂的平面，以使局部因子在子代之间不对称地分配。这篇综述描述了专门的皮质结构域如何在这些步骤的每一个中发挥关键作用，并讨论了我们目前对皮质结构域的分子性质及其协调不对称细胞分裂的机制的理解。