The arrival of a great number of new antineoplastic agents has made it necessary to reclassify all of them. Anticancer drugs may act at different levels: cancer cells, endothelium, extracellular matrix, the immune system or host cells. The tumour cell can be targeted at the DNA, RNA or protein level. Most classical chemotherapeutic agents interact with tumour DNA, whereas monoclonal antibodies and small molecules are directed against proteins. The endothelium and extracellular matrix may be affected also by specific antibodies and small molecules.

中文翻译：

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抗癌药物的分类-一种基于治疗目标的新系统。

大量新的抗肿瘤药的到来使得有必要对所有它们进行重新分类。抗癌药物可能以不同的水平起作用：癌细胞，内皮细胞，细胞外基质，免疫系统或宿主细胞。肿瘤细胞可以靶向DNA，RNA或蛋白质水平。大多数经典的化学治疗剂与肿瘤DNA相互作用，而单克隆抗体和小分子则针对蛋白质。内皮和细胞外基质也可能受到特异性抗体和小分子的影响。