The object of this review is to assemble much of the literature concerning Purkinje cell death in cerebellar pathology and to relate this to what is now known about the complex topography of the cerebellar cortex. A brief introduction to Purkinje cells, and their regionalization is provided, and then the data on Purkinje cell death in mouse models and, where appropriate, their human counterparts, have been arranged according to several broad categories--naturally-occurring and targeted mutations leading to Purkinje cell death, Purkinje cell death due to toxins, Purkinje cell death in ischemia, Purkinje cell death in infection and in inherited disorders, etc. The data reveal that cerebellar Purkinje cell death is much more topographically complex than is usually appreciated.

中文翻译：

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小脑浦肯野细胞死亡的模式。

本文的目的是收集有关小脑病理学中浦肯野细胞死亡的大量文献，并将其与目前已知的小脑皮质复杂地形有关。提供了Purkinje细胞及其区域化的简要介绍，然后根据以下几大类对小鼠模型以及适当情况下的人类模型中Purkinje细胞死亡的数据进行了整理-天然突变和靶向突变包括Purkinje细胞死亡，毒素引起的Purkinje细胞死亡，局部缺血中的Purkinje细胞死亡，感染和遗传性疾病中的Purkinje细胞死亡等。数据表明，小脑Purkinje细胞死亡的地形复杂性远高于通常的认识。