The possibility that magnetic fields (MF) cause antitumor activity in vivo has been investigated. Two different experiments have been carried out on nude mice bearing a subcutaneous human colon adenocarcinoma (WiDr). In the first experiment, significant increase in survival time (31%) was obtained in mice exposed daily to 70 min modulated MF (static with a superimposition of 50 Hz) having a time average total intensity of 5.5 mT. In the second independent experiment, when mice bearing tumors were exposed to the same treatment for four consecutive weeks, significant inhibition of tumor growth (40%) was reported, together with a decrement in tumor cell mitotic index and proliferative activity. A significant increase in apoptosis was found in tumors of treated animals, together with a reduction in immunoreactive p53 expression. Gross pathology at necroscopy, hematoclinical/hematological and histological examination did not show any adverse or abnormal effects. Since pharmacological rescue of mutant p53 conformation has been recently demonstrated, the authors suggest that MF exposure may obtain a similar effect by acting on redox chemistry connected to metal ions which control p53 folding and its DNA-binding activity. These findings support further investigation aimed at the potential use of magnetic fields as anti-cancer agents.

中文翻译：

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暴露于磁场后，小鼠存活率增加，肿瘤生长抑制作用和免疫反应性p53降低。

已经研究了磁场（MF）在体内引起抗肿瘤活性的可能性。已经对带有皮下人结肠腺癌（WiDr）的裸鼠进行了两个不同的实验。在第一个实验中，每天暴露于时间平均总强度为5.5 mT的70分钟调制MF（静态叠加50 Hz）的小鼠中，存活时间显着增加（31％）。在第二个独立的实验中，当荷瘤小鼠连续四周接受相同的治疗时，据报道肿瘤生长受到明显抑制（40％），肿瘤细胞的有丝分裂指数和增殖活性下降。在治疗的动物的肿瘤中发现凋亡的显着增加，以及免疫反应性p53表达的降低。肾镜检查，血液临床/血液学和组织学检查的大体病理未显示任何不良或异常影响。由于最近已经证明了突变体p53构象的药理学挽救作用，因此作者提出，MF暴露可通过作用于与控制p53折叠及其DNA结合活性的金属离子相连的氧化还原化学作用而获得类似的效果。这些发现支持进一步研究，旨在将磁场用作抗癌药。作者认为，MF暴露可能通过对与控制p53折叠及其DNA结合活性的金属离子相连的氧化还原化学起作用而获得类似的效果。这些发现支持进一步研究，旨在将磁场用作抗癌药。作者认为，MF暴露可能通过对与控制p53折叠及其DNA结合活性的金属离子相连的氧化还原化学起作用而获得类似的效果。这些发现支持进一步研究，旨在将磁场用作抗癌药。