当前位置: X-MOL 学术Immunol. Invest. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Indonesians Human Leukocyte Antigen (HLA) Distributions and Correlations with Global Diseases.
Immunological Investigations ( IF 2.9 ) Pub Date : 2019-10-24 , DOI: 10.1080/08820139.2019.1673771
Krisnawan Andy Pradana 1, 2 , Michael Anekson Widjaya 1 , Mariana Wahjudi 1
Affiliation  

In Human, Major Histocompatibility Complex known as Human Leukocyte Antigen (HLA). The HLA grouped into three subclasses regions: the class I region, the class II region, and the class III region. There are thousands of polymorphic HLAs, many of them are proven to have correlations with diseases. Indonesia consists of diverse ethnicity people and populations. It carries a unique genetic diversity between one and another geographical positions. This paper aims to extract Indonesians HLA allele data, mapping the data, and correlating them with global diseases. From the study, it is found that global diseases, like Crohn's disease, rheumatoid arthritis, Graves' disease, gelatin allergy, T1D, HIV, systemic lupus erythematosus, juvenile chronic arthritis, and Mycobacterial disease (tuberculosis and leprosy) suspected associated with the Indonesian HLA profiles.

中文翻译:

印尼人白细胞抗原(HLA)分布及其与全球疾病的关系。

在人类中,主要的组织相容性复合体称为人类白细胞抗原(HLA)。HLA分为三个子类区域:I类区域,II类区域和III类区域。有数千种多态HLA,其中许多已被证明与疾病相关。印度尼西亚由不同种族的人民和人口组成。它在一个和另一个地理位置之间具有独特的遗传多样性。本文旨在提取印尼人HLA等位基因数据,对数据进行映射,并将其与全球疾病相关联。从研究中发现,全球性疾病,例如克罗恩氏病,类风湿性关节炎,格雷夫斯氏病,明胶过敏,T1D,HIV,系统性红斑狼疮,青少年慢性关节炎,
更新日期:2020-03-28
down
wechat
bug