Introduction: The liver is the main location for metastasization in stage IV colorectal cancers.

Areas covered: This review intends to comprehensively present the most important studies conducted in the past few years concerning the role of miRNAs in colorectal cancer liver metastases, trying to clarify some aspects regarding tumor biology and favorite liver metastasization site.

Expert commentary: Recent advances in tissue and serum RNA extraction has considerably improved the field of microRNAs studies. These molecules known to play a crucial role in the metastatic stage indicate a starting point in the development of clinical biomarkers with a possible role in the stratification of high-risk patients for adequate treatment.

简介：肝脏是IV期大肠癌转移的主要部位。

涵盖的领域：这篇综述旨在全面介绍过去几年中有关miRNA在结肠直肠癌肝转移中的作用的最重要研究，试图阐明一些与肿瘤生物学和肝转移部位有关的方面。

专家评论：组织和血清RNA提取的最新进展大大改善了microRNA研究领域。这些已知在转移阶段起关键作用的分子表明了临床生物标志物开发的起点，可能对高危患者进行分层以进行适当治疗。