Engraftment syndrome (ES), a complication of autologous hematopoietic cell transplantation (auto-HCT), can occur around the time of neutrophil recovery. We sought to identify the incidence of ES in light chain (AL) amyloidosis patients undergoing auto-HCT at our centre by evaluating 72 consecutive amyloidosis patients transplanted between 1999 and 2017. To assess trends in ES over time, patients were divided into two Eras (Era 1 = 1999–2008 and Era 2 = 2009–2017) based on year of auto-HCT. Twenty-two (31%) patients developed ES; three (16%) and 19 (36%) in Era 1 and 2, respectively (p = .1). Three (16%) and 51 (96%) patients in Era 1 and 2 received chemotherapy before auto-HCT (p = <.001). The most common symptoms observed with ES in addition to fever was diarrhoea (73%), rash (68%), weight gain (56%) and non-cardiogenic pulmonary oedema (23%). Day 100 post-auto-HCT haematological response (19.5% vs. 14%, p = .7) or post-transplant best organ response (23% vs. 36%, p = .2) were not significantly different in patients who did not or did develop ES, respectively. In this single centre series, we define the incidence and characteristics of ES in AL amyloidosis patients undergoing auto-HCT.

植入综合征（ES）是自体造血细胞移植（auto-HCT）的并发症，可在中性粒细胞恢复期间发生。我们试图通过评估1999年至2017年间移植的72例连续淀粉样变性病患者来确定在我们中心接受自动HCT的轻链（AL）淀粉样变性患者中ES的发生率。为了评估ES随时间的变化趋势，将患者分为两个时代1年= 1999–2008年，2年= 2009–2017年）基于自动HCT年份。22名（31％）患者发展为ES；在第1代和第2代中分别有3个（16％）和19个（36％）（p  = .1）。在第1代和第2代中，分别有3（16％）和51（96％）位患者在进行自动HCT之前接受了化疗（p = <.001）。除发烧外，ES的最常见症状是腹泻（73％），皮疹（68％），体重增加（56％）和非心源性肺水肿（23％）。接受HCT的 患者在术后第100天的血液学反应（19.5％vs. 14％，p  = .7）或移植后最佳器官反应（23％vs. 36％，p = 0.2）没有显着差异。没有或确实开发了ES。在这个单一的中心系列中，我们定义了接受自动HCT的AL淀粉样变性患者中ES的发生率和特征。