Abstract Herein, we report the DNA interaction studies of rhenium(I) and -(V) compounds with Schiff base chelates encompassing biologically relevant moieties. More specifically, the DNA interaction capabilities of these rhenium complexes were probed using Gel Electrophoresis and Calf Thymus–DNA titrations monitored by temperature-controlled electronic spectroscopy. The DNA binding modes of the metal compounds were corroborated by molecular docking simulations. In addition, the synthesis and characterization of a novel facial tricarbonyl rhenium(I) compound, fac-[Re(chrs)(CO)3Br], (chrs = {3-{[(2-hydroxyphenyl)imino]methyl}-4H-chromen-4-one) are reported.

中文翻译：

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铼化合物与包含生物相关部分的席夫碱螯合物的 DNA 相互作用研究

摘要在此，我们报告了铼 (I) 和铼 (V) 化合物与包含生物相关部分的席夫碱螯合物的 DNA 相互作用研究。更具体地说，这些铼配合物的 DNA 相互作用能力是使用凝胶电泳和小牛胸腺-DNA 滴定法通过温控电子光谱法监测的。金属化合物的 DNA 结合模式通过分子对接模拟得到证实。此外，合成和表征了一种新型面部三羰基铼(I)化合物fac-[Re(chrs)(CO)3Br]，(chrs = {3-{[(2-羟基苯基)亚氨基]甲基}-4H -chromen-4-one) 报道。