ABSTRACT The study evaluated the effects of different doses of 25-hydroxyvitamin D3 (25(OH)D3) on growth performance, immune function and antioxidative capacity in piglets. In a 21-d trial, 35 weaned pigs were divided into five groups and diets were supplemented with 5.5 (control), 43.0, 80.5, 118.0 and 155.5 μg 25(OH)D3/kg, respectively. No treatment effects were observed for average daily gain, average daily feed intake and feed to gain ratio. Increasing dietary 25(OH)D3 levels increased serum 25(OH)D3 concentrations linearly (p < 0.01), decreased the frequency of CD3+CD4+ and CD3+CD8+ T cells (p < 0.01), and the serum level of complement component 3 (p < 0.05). Supplementation of 80.5 and 118.0 μg 25(OH)D3/kg enhanced the activity of serum glutathione peroxidase (p < 0.05) and addition of 43.0 μg 25(OH)D3/kg increased the malondialdehyde concentration (p < 0.05). Overall, feeding high-dose 25(OH)D3 to weaned pigs partly improved immune functions and the antioxidative capacity.

中文翻译：

---

日粮添加25-羟基维生素D3对断奶仔猪生长性能、免疫功能和抗氧化能力的影响

摘要 本研究评估了不同剂量的 25-羟基维生素 D3 (25(OH)D3) 对仔猪生长性能、免疫功能和抗氧化能力的影响。在为期 21 天的试验中，35 头断奶猪被分为五组，分别在日粮中添加 5.5（对照）、43.0、80.5、118.0 和 155.5 μg 25(OH)D3/kg。没有观察到平均日增重、平均日采食量和料重比的处理效果。增加膳食 25(OH)D3 水平会线性增加血清 25(OH)D3 浓度（p < 0.01），降低 CD3+CD4+ 和 CD3+CD8+ T 细胞的频率（p < 0.01），以及补体成分 3 的血清水平(p < 0.05)。补充 80.5 和 118.0 μg 25(OH)D3/kg 可增强血清谷胱甘肽过氧化物酶的活性（p < 0.05）并添加 43。0 μg 25(OH)D3/kg 增加丙二醛浓度（p < 0.05）。总体而言，断奶仔猪饲喂高剂量 25(OH)D3 部分改善了免疫功能和抗氧化能力。