Motile cilia of epithelial multiciliated cells transport vital fluids along organ lumens to promote essential respiratory, reproductive and brain functions. Progenitors of multiciliated cells undergo massive and coordinated organelle remodelling during their differentiation for subsequent motile ciliogenesis. Defects in multiciliated cell differentiation lead to severe cilia‐related diseases by perturbing cilia‐based flows. Recent work designated the machinery of mitosis as the orchestrator of the orderly progression of differentiation associated with multiple motile cilia formation. By examining the events leading to motile ciliogenesis with a methodological prism of mitosis, we contextualise and discuss the recent findings to broaden the spectrum of questions related to the differentiation of mammalian multiciliated cells.

中文翻译：

---

运动纤毛发生和有丝分裂棱镜

上皮多纤毛细胞的运动纤毛沿着器官腔运输重要的液体，以促进基本的呼吸、生殖和大脑功能。多纤毛细胞的祖细胞在其分化过程中经历了大规模和协调的细胞器重塑，用于随后的运动纤毛发生。多纤毛细胞分化缺陷通过扰乱基于纤毛的流动导致严重的纤毛相关疾病。最近的工作将有丝分裂机制指定为与多​​种运动纤毛形成相关的分化有序进展的协调者。通过使用有丝分裂的方法学棱镜检查导致运动纤毛发生的事件，我们将最近的发现置于情境中并进行讨论，以拓宽与哺乳动物多纤毛细胞分化相关的问题范围。