Chemotherapy‐induced peripheral neurotoxicity (CIPN) is a potentially dose‐limiting side effect of several commonly used cytotoxic chemotherapy agents. The main pharmacological classes that may cause CIPN include classical anticancer drugs, as well as the recently introduced immune checkpoint inhibitors and antibody drug conjugates. The absence of a complete knowledge of CIPN pathophysiology is only one of the several unsolved issues related to CIPN. Among some of the most relevant aspects of CIPN deserving further attention include the real number of patients exposed to the risk of CIPN, the long‐term impact on cancer survivors' quality of life due to incomplete recovery from CIPN, the economic burden related to acute and chronic CIPN, and the different perspective and education of the healthcare specialists in charge of managing patients with CIPN. Overall, CIPN remains a very challenging area of research as there are still several unresolved issues to be addressed in the future. In this special issue, the multifaceted profile of CIPN will be presented, with particular emphasis on bolstering the need to develop more optimized outcome measures than the existing ones to accurately evaluate the extent of CIPN, but also to ascertain the differences in the incidence, risk factors, clinical phenotype, and management of CIPN, according to the most commonly used neurotoxic chemotherapy classes. Perspectives for future research to pursue in order to cover the gaps in knowledge in the CIPN field will also be discussed.

中文翻译：

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化疗引起的周围神经毒性：一个多方面的、尚未解决的问题。


化疗引起的周围神经毒性（CIPN）是几种常用细胞毒性化疗药物的潜在剂量限制副作用。可能引起 CIPN 的主要药理学类别包括经典抗癌药物，以及最近推出的免疫检查点抑制剂和抗体药物偶联物。对 CIPN 病理生理学缺乏完整的了解只是与 CIPN 相关的几个未解决的问题之一。 CIPN 的一些最相关的方面值得进一步关注，包括暴露于 CIPN 风险的患者的实际数量、由于 CIPN 不完全恢复而对癌症幸存者生活质量的长期影响、与急性癌症相关的经济负担。和慢性 CIPN，以及负责管理 CIPN 患者的医疗保健专家的不同观点和教育。总体而言，CIPN 仍然是一个非常具有挑战性的研究领域，因为未来仍有一些未解决的问题需要解决。在本期特刊中，将介绍 CIPN 的多方面概况，特别强调需要制定比现有措施更优化的结果衡量标准，以准确评估 CIPN 的程度，同时确定发病率、风险的差异根据最常用的神经毒性化疗类别，了解 CIPN 的因素、临床表型和治疗。还将讨论未来研究的前景，以弥补 CIPN 领域的知识空白。