OBJECTIVE Migraine and major depressive disorder show a high rate of comorbidity, but little is known about the associations between the subtypes of major depressive disorder and migraine. In this cross-sectional study we aimed at investigating a) the lifetime associations between the atypical, melancholic, combined and unspecified subtype of major depressive disorder and migraine with and without aura and b) the associations between major depressive disorder and its subtypes and the severity of migraine. METHODS A total of 446 subjects with migraine (migraine without aura: n = 294; migraine with aura: n = 152) and 2511 controls from the population-based CoLaus/PsyCoLaus study, Switzerland, were included. Associations between major depressive disorder subtypes and migraine characteristics were tested using binary logistic or linear regression. RESULTS Melancholic, combined and unspecified major depressive disorder were associated with increased frequency of migraine with aura, whereas only melancholic major depressive disorder was associated with increased frequency of migraine without aura. Lifetime and unspecified major depressive disorder were associated with severe migraine intensity among subjects with migraine with aura but not migraine without aura, while combined major depressive disorder was associated with higher migraine frequency independently from migraine subtype. CONCLUSION This study suggests that melancholic but not atypical major depressive disorder is associated with migraine and migraine subtypes. Future studies exploring pathophysiological mechanisms shared between melancholic depression and migraine are warranted.

中文翻译：

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主要抑郁症亚型与偏头痛亚型，患病率和严重程度存在差异。

目的偏头痛和重度抑郁症合并症的发生率很高，但对重度抑郁症和偏头痛的亚型之间的关联知之甚少。在这项横断面研究中，我们旨在研究a）伴有或不伴有先兆的非典型，抑郁，合并和未明确的重度抑郁症和偏头痛亚型之间的终生关联； b）严重抑郁症及其亚型与严重性之间的关联偏头痛 方法总共纳入了来自瑞士的基于群体的CoLaus / PsyCoLaus研究的446名偏头痛患者（无先兆偏头痛：n = 294；有先兆偏头痛：n = 152）和2511名对照。主要抑郁症亚型与偏头痛特征之间的关联使用二元逻辑或线性回归进行了检验。结果忧郁，合并和未明确的重度抑郁症与先兆偏头痛发生率增加有关，而仅忧郁症重度抑郁症与无先兆偏头痛发生率增加有关。伴有先兆的偏头痛患者的终生和未明确的重度抑郁症与严重的偏头痛强度有关，而无先兆的偏头痛则与偏头痛的严重程度有关，而合并的重度抑郁症与偏头痛亚型无关地与偏头痛发生频率升高有关。结论这项研究表明，忧郁而非典型的重性抑郁症与偏头痛和偏头痛亚型有关。将来有必要探索忧郁症抑郁症和偏头痛之间共享的病理生理机制。合并和未明确的重度抑郁症与先兆偏头痛发生率增加有关，而仅忧郁症重度抑郁症与无先兆偏头痛发生率增加有关。伴有先兆的偏头痛患者的终生和未明确的重度抑郁症与严重的偏头痛强度有关，而无先兆的偏头痛则与偏头痛的严重程度有关，而合并的重度抑郁症与偏头痛亚型无关地与偏头痛发生频率升高有关。结论这项研究表明，忧郁而非典型的重性抑郁症与偏头痛和偏头痛亚型有关。将来有必要探索忧郁症抑郁症和偏头痛之间共享的病理生理机制。合并和未明确的重度抑郁症与先兆偏头痛发生率增加有关，而仅忧郁症重度抑郁症与无先兆偏头痛发生率增加有关。伴有先兆的偏头痛患者的终生和未明确的重度抑郁症与严重偏头痛强度有关，而无先兆的偏头痛则与偏头痛强度有关，而合并的重度抑郁症与偏头痛亚型无关地与偏头痛发生频率升高相关。结论这项研究表明，忧郁而非典型的重性抑郁症与偏头痛和偏头痛亚型有关。将来有必要探索忧郁症抑郁症和偏头痛之间共享的病理生理机制。