Its hydrophilic property and poor water resistance prevent the application of starch in electrospun nanofibers for biomedical applications. In this paper, we apply a periodate oxidation-adipic acid dihydrazide crosslinking strategy to electrospun starch nanofibers and develop a new nanofiber material with excellent mechanical strength, superior water resistance, and excellent cytocompatibility. The crosslinked starch nanofiber membranes exhibit a Young's modulus up to 2.65 MPa in the wet state, can maintain 91.0% of their initial mass after four weeks' incubation in simulated body fluid, and do not cause toxicity to L929 fibroblast cells. The control nanofibers prepared with a conventional glutaraldehyde crosslinking strategy show only a 60 kPa Young's modulus, retain only 31.9% of their initial mass after four weeks in simulated body fluid, and cause toxicity to cells. The crosslinked starch nanofibers with high mechanical strength, excellent water resistance and good biocompatibility are promising for biomedical applications.

中文翻译：

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具有高机械强度和出色的耐水性的交联淀粉纳米纤维，用于生物医学应用。

它的亲水性和差的耐水性阻止了淀粉在生物医学应用的电纺纳米纤维中的应用。在本文中，我们将高碘酸盐氧化－己二酸二酰肼交联策略应用于电纺淀粉纳米纤维，并开发出一种新型纳米纤维材料，该材料具有优异的机械强度，优异的耐水性和优异的细胞相容性。交联的淀粉纳米纤维膜在湿态下具有高达2.65 MPa的杨氏模量，在模拟体液中培养4周后可以保持其初始质量的91.0％，并且不会对L929成纤维细胞产生毒性。用常规戊二醛交联策略制备的对照纳米纤维仅显示60 kPa的杨氏模量，仅保留31。在模拟体液中放置4周后，其初始质量的9％会对细胞产生毒性。具有高机械强度，优异的耐水性和良好的生物相容性的交联淀粉纳米纤维有望用于生物医学应用。