The measles, mumps and rubella (MMR) vaccine has an outstanding safety record and is highly efficacious. High coverage with MMR has led to the elimination of endemic measles, rubella, and congenital rubella syndrome in the US. The biggest challenges to global measles and rubella control and elimination are insufficient vaccination coverage globally and increasing hesitancy. Despite high two dose coverage rates, mumps has made a resurgence in the US and other countries. Mumps outbreaks have occurred primarily in close contact, high-density settings and most cases had received a second dose 10 or more years previously. Waning humoral immunity and antigenic variation of circulating wild-type mumps strains may play a role in the mumps resurgence.

麻疹，腮腺炎和风疹（MMR）疫苗具有出色的安全记录，并且非常有效。MMR的高覆盖率导致在美国消除了地方性麻疹，风疹和先天性风疹综合症。全球麻疹，风疹控制和消除的最大挑战是全球疫苗接种覆盖率不足和犹豫。尽管两次剂量覆盖率很高，但流行性腮腺炎在美国和其他国家也重新流行。流行性腮腺炎的暴发主要发生在密切接触，高密度环境中，大多数病例在十年或更早以前就已经接受了第二剂。循环野生型腮腺炎菌株的体液免疫力下降和抗原变异可能在腮腺炎的复发中起作用。