OBJECTIVES To study the role of inflammatory chemokine; monocyte chemoattractant protein-1 (MCP-1), and fibrogenic markers [transforming growth factor beta-1 (TGF-β(1)), connective tissue growth factor (CTGF) and fibronectin (FN)] in diabetic nephropathy (DN). DESIGN AND METHODS This study included 17 control and 65 type 2 diabetic subjects (18 normoalbuminuric, 22 microalbuminuric and 25 macroalbuminuric). Demographic characteristics, diabetic index and kidney function tests were monitored. Serum TGF-β(1), plasma CTGF, MCP-1 and FN levels were assayed. RESULTS Microalbuminuric and macroalbuminuric subjects showed a significant elevation in TGF-β(1), CTGF, MCP-1 and FN levels as compared with control and normoalbuminuric subjects. There was positive correlation between these markers and fasting plasma glucose, albumin excretion rate and with each other. CONCLUSION This study revealed the importance of these markers in DN pathogenesis which is powered by their association and thus the possibility of their use as biochemical markers in DN was suggested.

中文翻译：

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糖尿病肾病中炎症和纤维化细胞因子的临床意义。

目的研究炎症趋化因子的作用。糖尿病肾病（DN）中的单核细胞趋化蛋白1（MCP-1）和纤维化标志物[转化生长因子β-1（TGF-β（1）），结缔组织生长因子（CTGF）和纤连蛋白（FN）]。设计与方法本研究包括17名对照和65名2型糖尿病受试者（18名白蛋白尿，22名微蛋白尿和25名大蛋白尿）。监测人口统计学特征，糖尿病指数和肾功能检查。测定血清TGF-β（1），血浆CTGF，MCP-1和FN水平。结果微白蛋白尿和大白蛋白尿的受试者与对照组和正常白蛋白尿的受试者相比，TGF-β（1），CTGF，MCP-1和FN水平显着升高。这些标志物与空腹血糖呈正相关，白蛋白排泄率与彼此有关。结论这项研究揭示了这些标记物在DN发病机理中的重要性，这是由它们之间的联系所驱动的，因此提出了将其用作DN中生化标记物的可能性。