Cardiovascular disorders and predominantly idiopathic myocardial fibrosis are frequently associated with mortality among zoo-housed chimpanzees (Pan troglodytes). Formalin-fixed whole hearts of deceased chimpanzees housed in zoos (n = 33) and an African sanctuary (n = 2) underwent detailed macroscopic and histopathologic examination using a standardized protocol. Archived histological slides from the hearts of 23 additional African sanctuary-housed chimpanzees were also examined. Myocardial fibrosis (MF) was identified in 30 of 33 (91%) of the zoo-housed chimpanzees but none of the 25 sanctuary-housed chimpanzees. MF was shown to be characterized by both interstitial and replacement fibrosis. Immunophenotyping demonstrated that the fibrotic lesions were accompanied by the increased presence of macrophages, alpha smooth muscle actin-positive myofibroblasts, and a minimal to mild T-cell-dominant leukocyte infiltration. There was no convincing evidence of cardiotropic viral infection or suggestion that diabetes mellitus or vitamin E or selenium deficiency were associated with the presence of the lesion. However, serum vitamin D concentrations among zoo-housed chimpanzees were found to be lower in seasons of low ultraviolet light levels.

中文翻译：

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圈养黑猩猩（盘状穴居人）的特发性心肌纤维化。

在动物园饲养的黑猩猩（潘氏穴居人）中，心血管疾病和主要为特发性心肌纤维化通常与死亡率相关。动物园（n = 33）和非洲庇护所（n = 2）内已死者黑猩猩的福尔马林固定全心，使用标准化方案进行了详细的宏观和组织病理学检查。还检查了另外23个非洲庇护所内黑猩猩心脏的存档组织学幻灯片。在33只动物园中的黑猩猩中有30只（91％）识别出了心肌纤维化（MF），但25只庇护所中的黑猩猩中均未发现心肌纤维化。MF表现为间质性和替代性纤维化。免疫分型显示纤维化病变伴有巨噬细胞增多，α平滑肌肌动蛋白阳性的肌成纤维细胞，以及少量至轻度的以T细胞为主的白细胞浸润。没有令人信服的心脏疾病病毒感染的证据，也没有暗示糖尿病，维生素E或硒缺乏与病变的存在有关。但是，发现在紫外线强度较低的季节，动物园饲养的黑猩猩的血清维生素D浓度较低。