BackgroundThis study estimated genital warts prevalence, genital-warts-related healthcare resource use and costs, and self-reported human-papillomavirus-related psychosocial impact among male and female patients aged 18–60 years in the Philippines.MethodsPrevalence was estimated using daily logs numbering genital warts patients treated by participating physicians in 4 Philippine regions over a 5-week period (09JUL2011-24SEP2012). Physicians also completed a survey assessing patient referral patterns, healthcare resource use, treatment, and follow-up care. Psychosocial impact was estimated using the human papillomavirus impact profile and the EQ-5D questionnaires. HIP and EQ-5D scores were compared according to the presence of GW (males) and HPV disease (females). CECA scores were also compared by gender and age groups.ResultsOverall genital warts prevalence was estimated at 4.78% (95% confidence interval [CI]: 4.58–4.98%) for men and women aged 18–60 years. Genital warts prevalence was 3.39% (95% CI: 3.13–3.65%) and 8.0% (95% CI: 7.69–8.31%) among women and men, respectively. Prevalence estimates were highest in infectious disease specialist practices 18.67% (95% CI: 18.66–18.69%). Two thirds of the 233 (69.14%) male and 166 (67.20%) female patients were newly-diagnosed genital warts cases. Median costs for genital warts diagnosis and treatment reached 7121 and 7000 Philippine pesos among men and women, respectively. In the Cuestionario Específico para Condiloma Acuminado questionnaire, no statistically significant differences between patients were observed. In the EQ-5D questionnaire, male genital warts patients reported lower mean visual analogue scale scores than those without genital warts (78.20 vs 86.34, p < 0.0001). Mean visual analogue scale score values and utility values were lower for women with human-papillomavirus-related diseases than those without (77.98 vs 78.93, and 0.84 vs 0.88, respectively).ConclusionsGenital warts is prevalent in the Philippines; more than 60% of cases were newly diagnosed, contributing to high genital-warts-related healthcare resource costs. Diagnosis of genital warts and human papillomavirus negatively impacted psychosocial indices such as patient well-being and health-related quality of life.

中文翻译：

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估计菲律宾尖锐湿疣相关疾病负担：一项具有全国代表性的横断面研究

背景这项研究估计了菲律宾 18-60 岁男性和女性患者的尖锐湿疣患病率、尖锐湿疣相关的医疗资源使用和成本，以及自我报告的人类乳头瘤病毒相关的社会心理影响。方法使用每日日志编号估计患病率4 个菲律宾地区的参与医师在 5 周内对生殖器疣患者进行了治疗 (09JUL2011-24SEP2012)。医生还完成了一项评估患者转诊模式、医疗资源使用、治疗和后续护理的调查。使用人乳头瘤病毒影响概况和 EQ-5D 问卷估计社会心理影响。根据 GW（男性）和 HPV 疾病（女性）的存在比较 HIP 和 EQ-5D 评分。还按性别和年龄组比较了 CECA 分数。结果 18-60 岁男性和女性的总体尖锐湿疣患病率估计为 4.78%（95% 置信区间 [CI]：4.58-4.98%）。女性和男性的尖锐湿疣患病率分别为 3.39%（95% CI：3.13-3.65%）和 8.0%（95% CI：7.69-8.31%）。传染病专家实践中的患病率估计最高，为 18.67%（95% CI：18.66–18.69%）。233名（69.14%）男性和166名（67.20%）女性患者中有三分之二是新诊断的尖锐湿疣病例。生殖器疣诊断和治疗的中位数成本分别达到男性和女性的 7121 和 7000 菲律宾比索。在 Cuestionario Específico para Condiloma Acuminado 问卷中，未观察到患者之间的统计学显着差异。在 EQ-5D 问卷中，男性尖锐湿疣患者报告的平均视觉模拟评分低于没有尖锐湿疣的患者（78.20 vs 86.34，p < 0.0001）。患有人乳头瘤病毒相关疾病的女性的平均视觉模拟量表评分值和效用值低于未患有人乳头瘤病毒相关疾病的女性（分别为 77.98 对 78.93 和 0.84 对 0.88）。超过 60% 的病例是新诊断的，导致与尖锐湿疣相关的医疗资源成本很高。尖锐湿疣和人乳头瘤病毒的诊断对心理社会指标产生负面影响，例如患者的幸福感和与健康相关的生活质量。患有人乳头瘤病毒相关疾病的女性的平均视觉模拟量表评分值和效用值低于未患有人乳头瘤病毒相关疾病的女性（分别为 77.98 对 78.93 和 0.84 对 0.88）。超过 60% 的病例是新诊断的，导致与尖锐湿疣相关的医疗资源成本很高。尖锐湿疣和人乳头瘤病毒的诊断对心理社会指标产生负面影响，例如患者的幸福感和与健康相关的生活质量。患有人乳头瘤病毒相关疾病的女性的平均视觉模拟量表评分值和效用值低于未患有人乳头瘤病毒相关疾病的女性（分别为 77.98 对 78.93 和 0.84 对 0.88）。超过 60% 的病例是新诊断的，导致与尖锐湿疣相关的医疗资源成本很高。尖锐湿疣和人乳头瘤病毒的诊断对心理社会指标产生负面影响，例如患者的幸福感和与健康相关的生活质量。