Since the advent of organ-on-a-chip, many researchers have tried to mimic the physiology of human tissue on an engineered platform. In the case of brain tissue, structural connections and cell-cell interactions are important factors for brain function. The recent development of brain-on-a-chip is an effort to mimic those structural and functional aspects of brain tissue within a miniaturized engineered platform. From this perspective, we provide an overview of trace of brain-on-a-chip development, especially in terms of complexity and high-content/high-throughput screening capabilities, and future perspectives on more in vivo-like brain-on-a-chip development.

中文翻译：

---

片上大脑：发展历史和未来展望。

自从芯片器官出现以来，许多研究人员试图在工程平台上模拟人体组织的生理学。就脑组织而言，结构连接和细胞间相互作用是大脑功能的重要因素。芯片大脑的最新发展是为了在微型工程平台内模拟脑组织的结构和功能。从这个角度，我们概述了芯片脑的发展轨迹，特别是在复杂性和高内涵/高通量筛选能力方面，以及未来对更多类似体内芯片脑的展望。 -芯片开发。