We present a female patient, 13 years old, with diagnosis of hepatocellular carcinoma of fibrolamellar type, which was rapidly evolving. The fibrolamellar hepatocellular carcinoma invaded more than 80% of the hepatic parenchyma without surgical possibility or liver transplantation. Measures applied corresponded to chemotherapy of 1 cycle of cisplatin 40 mg/s/5 days + vincristine 1.5 mg/m2/day, 5-fluorouracil, doxorubicin, and dexrazoxane. The case presented aggressive evolution of hepatocellular carcinoma, which led to acute liver failure, with hyperammonemia, sepsis, pulmonary focus plus septic shock, grade III-IV encephalopathy, portal hypertension, and ascites with intra-abdominal hypertension. Death occurred due to multiple organ failure, which involved respiratory failure type KDIGO 1 and 2, acute liver failure, severe pneumonia, pericardial effusion, AKIN 2 acute kidney injury, carcinoma, and pulmonary metastasis. This type of ailment is infrequent in children and adolescents, and the first symptoms are crucial to achieve treatment possibilities.

中文翻译：

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青少年纤维板层型肝细胞癌：病例报告和文献复习。

我们介绍了一名 13 岁的女性患者，她被诊断为纤维板层型肝细胞癌，并且进展迅速。纤维板层肝细胞癌侵犯了 80% 以上的肝实质，没有手术或肝移植的可能。所应用的措施对应于顺铂 40 mg/s/5 天 + 长春新碱 1.5 mg/m2/天、5-氟尿嘧啶、多柔比星和右雷佐生 1 个周期的化疗。该病例表现为肝细胞癌的侵袭性进展，导致急性肝功能衰竭、高氨血症、败血症、肺病灶加感染性休克、III-IV 级脑病、门脉高压和腹水伴腹内高压。死因是多器官功能衰竭，包括 KDIGO 1 型和 2 型呼吸衰竭、急性肝衰竭、重症肺炎、心包积液、AKIN 2 急性肾损伤、癌和肺转移。这种类型的疾病在儿童和青少年中并不常见，最初的症状对于实现治疗可能性至关重要。