Gene-editing technologies have improved in ease, efficiency, and precision. Although discussions are occurring around acceptable uses of human gene editing, limited data exist on the views of genetics-trained individuals. In 2017, we distributed an anonymous online survey to assess the attitudes of members of genetics professional societies toward gene editing (N = 500). Virtually all respondents were supportive of somatic editing in basic-science (99.2%) and clinical (87.4%) research on nonreproductive human cells. Only 57.2% were supportive of germline-editing basic-science research; 31.9% supported the transfer of viable embryos to humans for clinical research. While most favored future therapeutic uses of somatic (96.6%) and germline (77.8%) editing, there was little support for enhancement in somatic (13.0%) or germline (8.6%) cells. This study describes attitudes toward gene editing from genetics professionals worldwide and contributes to ongoing discourse and policy guidance in this domain.

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遗传学专业协会成员对人类基因编辑的态度。

基因编辑技术在易用性、效率和精确度方面都有所提高。尽管围绕人类基因编辑的可接受用途进行了讨论，但关于受过遗传学训练的个人观点的数据有限。2017 年，我们发布了一项匿名在线调查，以评估遗传学专业协会成员对基因编辑的态度（N = 500）。几乎所有受访者都支持在非生殖人类细胞的基础科学 (99.2%) 和临床 (87.4%) 研究中进行体细胞编辑。只有 57.2% 的人支持种系编辑基础科学研究；31.9% 的人支持将活胚胎移植给人类进行临床研究。虽然最受青睐的未来治疗用途是体细胞 (96.6%) 和种系 (77.8%) 编辑，但几乎没有支持增强体细胞 (13.0%) 或种系 (8.6%) 细胞。