We describe in this work an advanced microfluidic chip for the capture of bioanalyte on the surface of droplets arranged in a dense array. We show the procedure for generating, functionalizing, and arranging the droplets inside the device for capturing a specific bioanalyte. Then, we demonstrate the capacity of the array to capture analyte from a cross-flowing liquid, using a biotin/streptavidin model. The paper also proposes to use the droplets array, after integration with acoustic detection, as a regenerable detection interface for bioanalyte sensing. We model the arrangement of droplet in dense array and show that they present a larger effective capture surface and shorter capture distance than standard flat surface biosensor of the same footprint. As the droplets can be easily evacuated and replaced inside the device analysis chamber, the proposed biosensor would allow biointerface regeneration and chain measurement without dismounting the device.

中文翻译：

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用于可再生生物传感器的功能化液滴阵列中的分析物捕获。

我们在这项工作中描述了一种先进的微流控芯片，用于捕获排列成密集阵列的液滴表面上的生物分析物。我们展示了用于生成，功能化和排列液滴以捕获特定生物分析物的设备内部的过程。然后，我们使用生物素/链霉亲和素模型演示了阵列从错流液体中捕获分析物的能力。该论文还建议在与声学检测集成后，将液滴阵列用作生物分析物感测的可再生检测接口。我们模拟了液滴在密集阵列中的排列，并显示与相同足迹的标准平面生物传感器相比，它们呈现出更大的有效捕获表面和更短的捕获距离。由于液滴很容易排空并在设备分析室内进行替换，