Abstract Introduction A previous study on canine babesiosis showed low serum tonicity in affected dogs, which may result from syndrome of inappropriate antidiuretic hormone secretion (SIADH). This endocrine disorder was recognised in human malaria which is considered a disease with similar pathogenesis to canine babesiosis. The aim of this study was to investigate the occurrence of SIADH in babesiosis-afflicted dogs. Material and Methods Serum and urinary sodium and urine specific gravity (USG) were determined in dogs with babesiosis. Mean arterial pressure (MAP) was measured at the beginning of the clinical examination. Serum tonicity and osmolality were calculated. Correlations were calculated between MAP and serum and urinary sodium concentrations, USG, serum tonicity, and calculated serum osmolality. Results Statistically significant correlations were observed between MAP and tonicity, calculated osmolality, USG, and serum and urinary sodium concentrations in non-azotaemic dogs. In three non-azotaemic dogs SIADH was recognised. Conclusion SIADH develops in non-azotaemic dogs with babesiosis. It is probably associated with decreased blood pressure in infected dogs. Thus, it seems that in fact it may be appropriate vasopressin secretion in canine babesiosis as a protective mechanism in hypotension which leads to hypoxia and renal failure in affected dogs.

中文翻译：

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巴贝虫病伴动脉血压降低的非氮质血症犬低钠血症和抗利尿激素分泌不当综合征

摘要 引言 先前关于犬巴贝斯虫病的研究表明，受影响的狗的血清张力低，这可能是由抗利尿激素分泌不当综合征 (SIADH) 引起的。这种内分泌紊乱在人类疟疾中得到认可，被认为是一种与犬巴贝斯虫病发病机制相似的疾病。本研究的目的是调查受巴贝虫病影响的狗中 SIADH 的发生情况。材料和方法 测定患有巴贝虫病的狗的血清和尿钠和尿比重（USG）。在临床检查开始时测量平均动脉压（MAP）。计算血清张力和渗透压。计算 MAP 与血清和尿钠浓度、USG、血清张力和计算的血清渗透压之间的相关性。结果在非氮质血症狗的 MAP 和张力、计算的渗透压、USG 以及血清和尿钠浓度之间观察到统计学上显着的相关性。在三只非氮质血症的狗中，SIADH 被识别。结论 SIADH 在患有巴贝虫病的非氮质血症犬中发生。它可能与受感染狗的血压降低有关。因此，似乎事实上，犬巴贝斯虫病中适当的加压素分泌可能是低血压的保护机制，导致受影响的狗缺氧和肾功能衰竭。它可能与受感染狗的血压降低有关。因此，似乎事实上，犬巴贝斯虫病中适当的加压素分泌可能是低血压的保护机制，导致受影响的狗缺氧和肾功能衰竭。它可能与受感染狗的血压降低有关。因此，似乎事实上，犬巴贝斯虫病中适当的加压素分泌可能是低血压的保护机制，导致受影响的狗缺氧和肾功能衰竭。