Nanoparticle drug delivery systems have been used in the clinic since the early 1990's. Since that time, the field of nanomedicine has evolved alongside growing technological needs to improve the delivery of various therapeutics. Over these past decades, newer generations of nanoparticles have emerged that are capable of performing additional delivery functions that can enable treatment via new therapeutic modalities. In the current clinical landscape, many of these new generation nanoparticles have reached clinical trials and have been approved for various indications. In the first issue of Bioengineering & Translational Medicine in 2016, we reviewed the history, current clinical landscape, and clinical challenges of nanoparticle delivery systems. Here, we provide a 3 year update on the current clinical landscape of nanoparticle drug delivery systems and highlight newly approved nanomedicines, provide a status update on previous clinical trials, and highlight new technologies that have recently entered the clinic.

中文翻译：

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临床中的纳米颗粒：更新。

自 20 世纪 90 年代初起，纳米颗粒药物输送系统就已应用于临床。从那时起，纳米医学领域随着改善各种治疗方法的技术需求不断增长而不断发展。在过去的几十年里，新一代的纳米粒子已经出现，它们能够执行额外的递送功能，从而能够通过新的治疗方式进行治疗。在当前的临床环境中，许多新一代纳米颗粒已进入临床试验并已被批准用于各种适应症。在2016年第一期《生物工程与转化医学》中，我们回顾了纳米颗粒递送系统的历史、当前的临床状况和临床挑战。在这里，我们提供了纳米颗粒药物输送系统当前临床状况的 3 年更新，并重点介绍了新批准的纳米药物，提供了先前临床试验的状态更新，并重点介绍了最近进入临床的新技术。