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Bioinorganic Markers of a Loss of the Crystalline Lens Capsule Barrier Properties and Consequent Age-Related Cataract Development.
Doklady Biological Sciences Pub Date : 2019-09-30 , DOI: 10.1134/s0012496619040070
N A Pakhomova 1 , T E Borisenko 1 , I A Novikov 1 , S E Avetisov 1, 2
Affiliation  

The age-related cataract development consequent upon a loss of the lens capsule barrier properties proved to be associated with accumulation of sodium, calcium, phosphorus and potassium. For the first time the use of spatial cluster and correlation analyses showed that the physical light scattering in the crystalline lens volume depends on changes in the lens matter elemental composition. The fields of elevated concentrations of sodium, calcium, phosphorus, potassium and chlorine conformed to the lens capsule geometry and their clustering was similar to that of opacity fields in the lens body. The accumulation geometry of the elements in the lens body that are commonly seen in the aqueous humor of the anterior chamber, can be considered evidence for excessive transitioning of their compounds through the lens capsule shell, while its spatial connection with transparency changes-proof of participation in cataractogenesis.

中文翻译:

晶状体晶状体晶状体屏障特性丧失和随之而来的年龄相关性白内障发展的生物无机标记。

晶状体囊屏障性质的丧失导致与年龄有关的白内障发展,其与钠,钙,磷和钾的积累有关。首次使用空间聚类和相关分析表明,晶状体体积中的物理光散射取决于晶状体元素组成的变化。钠,钙,磷,钾和氯的浓度升高的场与晶状体囊的几何形状相符,并且它们的聚集与晶状体中的不透明场相似。在前房房水中常见的晶状体中元素的累积几何形状,可以认为是其化合物通过晶状体囊壳过度过渡的证据,
更新日期:2019-11-01
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