STUDY OBJECTIVE The objective was to examine the association between sleep quality and global and domain-specific cognitive function among older individuals with type 1 diabetes (T1D). METHODS We evaluated 695 individuals with T1D aged 60 years or above who participated in the baseline assessment of the Study of Longevity in Diabetes (SOLID), which captured subjective sleep quality (Pittsburgh Sleep Quality Index) and global and domain-specific (language, executive function, episodic memory, and simple attention) cognitive function. Multivariable linear regressions estimated the associations between sleep quality quartiles and overall and domain-specific cognitive function adjusting for age, sex, race/ethnicity, education, depressive symptoms, and severe hypoglycemic episodes. Sensitivity analyses examined the associations between aspects of sleep quality and global cognitive function. RESULTS The worst sleep quality quartile was associated with lower global cognition (β=-0.08; 95% confidence interval: -0.17, -0.01) and lower executive function (β=-0.17, 95% confidence interval: -0.30, -0.03) compared with the best quartile of sleep quality adjusting for demographics and comorbidities. Sleep quality was not associated with language, episodic memory, or simple attention. Sleep medications and daytime dysfunction were most strongly associated with global cognition. CONCLUSION Our results suggest that sleep quality may be a modifiable risk factor for global cognitive function and executive function among elderly individuals with T1D.

中文翻译：

---

1型糖尿病的睡眠质量和认知功能：糖尿病长寿研究的发现（SOLID）。

研究目的目的是研究老年1型糖尿病（T1D）患者的睡眠质量与整体和特定领域认知功能之间的关系。方法我们评估了695名60岁或以上的T1D患者，他们参加了糖尿病长寿研究（SOLID）的基线评估，该研究收集了主观睡眠质量（匹兹堡睡眠质量指数）以及全球和特定领域的睡眠（语言，执行力）。功能，情景记忆和简单注意）认知功能。多变量线性回归估计了睡眠质量四分位数与针对年龄，性别，种族/族裔，教育程度，抑郁症状和严重降血糖事件而进行调整的整体和特定领域认知功能之间的关联。敏感性分析检查了睡眠质量与整体认知功能之间的关联。结果最差的睡眠质量四分位数与较低的整体认知度（β= -0.08; 95％置信区间：-0.17，-0.01）和较低的执行功能（β= -0.17，95％置信区间：-0.30，-0.03）相关与针对人口和合并症进行调整的最佳睡眠质量四分位数相比。睡眠质量与语言，发作性记忆或简单注意无关。睡眠药物和白天功能障碍与整体认知密切相关。结论我们的结果表明，睡眠质量可能是T1D老年患者整体认知功能和执行功能的可改变危险因素。结果最差的睡眠质量四分位数与较低的整体认知度（β= -0.08; 95％的置信区间：-0.17，-0.01）和较低的执行功能（β= -0.17，95％的置信区间：-0.30，-0.03）相关与针对人口和合并症进行调整的最佳睡眠质量四分位数相比。睡眠质量与语言，发作性记忆或简单注意无关。睡眠药物和白天功能障碍与整体认知密切相关。结论我们的结果表明，睡眠质量可能是T1D老年患者整体认知功能和执行功能的可改变危险因素。结果最差的睡眠质量四分位数与较低的整体认知度（β= -0.08; 95％的置信区间：-0.17，-0.01）和较低的执行功能（β= -0.17，95％的置信区间：-0.30，-0.03）相关与针对人口和合并症进行调整的最佳睡眠质量四分位数相比。睡眠质量与语言，发作性记忆或简单注意无关。睡眠药物和白天功能障碍与整体认知密切相关。结论我们的研究结果表明，睡眠质量可能是老年T1D患者整体认知功能和执行功能的可改变危险因素。03）与针对人口和合并症进行调整的最佳睡眠质量四分位数进行比较。睡眠质量与语言，发作性记忆或简单注意无关。睡眠药物和白天功能障碍与整体认知密切相关。结论我们的研究结果表明，睡眠质量可能是老年T1D患者整体认知功能和执行功能的可改变危险因素。03）与针对人口和合并症进行调整的最佳睡眠质量四分位数进行比较。睡眠质量与语言，发作性记忆或简单注意无关。睡眠药物和白天功能障碍与整体认知密切相关。结论我们的研究结果表明，睡眠质量可能是老年T1D患者整体认知功能和执行功能的可改变危险因素。